Reglan
Generic Name: metoclopramide (MET oh KLOE pra mide)
Brand Names: Metozolv ODT, Reglan
What is Reglan?
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Reglan (metoclopramide) increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.
Reglan is used short-term to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief of symptoms.
Reglan may also be used for purposes not listed in this medication guide.
Important information about Reglan
NEVER TAKE REGLAN IN LARGER AMOUNTS THAN RECOMMENDED, OR FOR LONGER THAN 12 WEEKS. High doses or long-term use of Reglan can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include tremors or other uncontrollable muscle movements. The longer you take metoclopramide, the more likely you are to develop a serious movement disorder. The risk of this side effect is higher in women, diabetics, and older adults.
You should not take Reglan if you are allergic to metoclopramide, or if you have bleeding or blockage in your stomach or intestines, epilepsy or other seizure disorder, or an adrenal gland tumor (pheochromocytoma).
Before you take Reglan, tell your doctor if you have kidney or liver disease, congestive heart failure, high blood pressure, diabetes, Parkinson's disease, or a history of depression.
Do not drink alcohol. It can increase some of the side effects of Reglan. There are many other medicines that can interact with metoclopramide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Stop using Reglan and call your doctor at once if you have tremors or uncontrolled muscle movements, fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing, depressed mood, thoughts of suicide or hurting yourself, hallucinations, anxiety, agitation, seizure, or jaundice (yellowing of your skin or eyes).
Before taking Reglan
You should not take Reglan if you are allergic to metoclopramide, or if you have:
bleeding or blockage in your stomach or intestines;
a perforation (hole) in your stomach or intestines;
epilepsy or other seizure disorder; or
an adrenal gland tumor (pheochromocytoma).
To make sure you can safely take Reglan, tell your doctor if you have any of these other conditions:
kidney disease;
liver disease (especially cirrhosis);
congestive heart failure;
high blood pressure;
Parkinson's disease;
diabetes (your insulin dose may need adjusting); or
a history of depression.
FDA pregnancy category B. Reglan is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Metoclopramide can pass into breast milk and may harm a nursing baby. Do not use Reglan without telling your doctor if you are breast-feeding a baby. Reglan should not be given to a child.
See also: Reglan pregnancy and breastfeeding warnings (in more detail)
How should I take Reglan?
NEVER TAKE REGLAN IN LARGER AMOUNTS THAN RECOMMENDED, OR FOR LONGER THAN 12 WEEKS. High doses or long-term use of Reglan can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include tremors or other uncontrollable muscle movements. The longer you take metoclopramide, the more likely you are to develop a serious movement disorder. The risk of this side effect is higher in women, diabetics, and older adults.
Take Reglan exactly as prescribed by your doctor. Reglan is usually taken for only 4 to 12 weeks. Follow the directions on your prescription label.
Take Reglan 30 minutes before eating. Reglan is usually taken before meals and at bedtime. Your doctor may want you to take the medication as needed only with meals that usually cause heartburn. Follow your doctor's instructions.
Measure the liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Store Reglan at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
After you stop taking Reglan, you may have unpleasant withdrawal symptoms such as headache, dizziness, or nervousness. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include drowsiness, confusion, tremors or uncontrolled muscle movements in your face or neck, or seizure (convulsions).
What should I avoid while taking Reglan?
Avoid drinking alcohol. It can increase some of the side effects of this medicine. Reglan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Reglan side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Reglan: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Reglan and call your doctor at once if you have any of these serious side effects:
tremors, or restless muscle movements in your eyes, tongue, jaw, neck, arms, or legs;
mask-like appearance of the face;
very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
depressed mood, thoughts of suicide or hurting yourself;
hallucinations, anxiety, agitation, jittery feeling, trouble staying still;
swelling, fluid retention;
jaundice (yellowing of your skin or eyes); or
seizure (convulsions).
Less serious Reglan side effects may include:
feeling restless, drowsy, tired, or dizzy;
headache, sleep problems (insomnia);
nausea, vomiting, diarrhea;
breast tenderness or swelling;
changes in your menstrual periods; or
urinating more than usual.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Reglan side effects (in more detail)
What other drugs will affect Reglan?
Before using Reglan, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Reglan.
Tell your doctor about all other medications you use, especially:
acetaminophen (Tylenol);
cyclosporine (Gengraf, Neoral, Sandimmune);
digoxin (digitalis, Lanoxin);
glycopyrrolate (Robinul);
insulin;
levodopa (Larodopa, Atamet, Parcopa, Sinemet);
mepenzolate (Cantil);
tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap);
atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);
bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);
irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), or propantheline (Pro-Banthine);
an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate); or
medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), haloperidol (Haldol), olanzapine (Zyprexa, Symbyax), prochlorperazine (Compazine), risperidone (Risperdal), thiothixene (Navane), and others.
This list is not complete and there are many other drugs that can interact with Reglan. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
More Reglan resources
Reglan Side Effects (in More Detail)
Reglan Use in Pregnancy & Breastfeeding
Drug Images
Reglan Drug Interactions
Reglan Support Group
30 Reviews for Reglan - Add your own review/rating
Reglan Prescribing Information (FDA)
Reglan Advanced Consumer (Micromedex) - Includes Dosage Information
Reglan Monograph (AHFS DI)
Reglan MedFacts Consumer Leaflet (Wolters Kluwer)
Metoclopramide Professional Patient Advice (Wolters Kluwer)
Metozolv ODT Orally Disintegrating Tablets MedFacts Consumer Leaflet (Wolters Kluwer)
Metozolv ODT Prescribing Information (FDA)
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Where can I get more information?
Your pharmacist can provide more information about Reglan.
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